FOXA1 antibody (AA 367-472)

Catalog No. ABIN7155051

The Rabbit Polyclonal anti-FOXA1 antibody has been validated for IHC and ELISA. It is suitable to detect FOXA1 in samples from Human.

Quick Overview for FOXA1 antibody (AA 367-472) (ABIN7155051)

Target: FOXA1 (Forkhead Box A1 (FOXA1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FOXA1 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA

Product Details anti-FOXA1 Antibody

Binding Specificity: AA 367-472

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Hepatocyte nuclear factor 3-alpha protein (367-472AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for FOXA1

Target: FOXA1 (Forkhead Box A1 (FOXA1))

Alternative Name: FOXA1

Background:

Background: Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a \'pioneer\' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5\'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3\' (By similarity). Proposed to play a role in translating the epigenetic signatures into cell type-specific enhancer-driven transcriptional programs. Its differential recruitment to chromatin is dependent on distribution of histone H3 methylated at \'Lys-5\' (H3K4me2) in estrogen-regulated genes. Involved in the development of multiple endoderm-derived organ systems such as liver, pancreas, lung and prostate, FOXA1 and FOXA2 seem to have at least in part redundant roles (By similarity). Modulates the transcriptional activity of nuclear hormone receptors. Is involved in ESR1-mediated transcription, required for ESR1 binding to the NKX2-1 promoter in breast cancer cells, binds to the RPRM promoter and is required for the estrogen-induced repression of RPRM. Involved in regulation of apoptosis by inhibiting the expression of BCL2. Involved in cell cycle regulation by activating expression of CDKN1B, alone or in conjunction with BRCA1. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis.

Aliases: forkhead box A1 antibody, Forkhead box protein A1 antibody, FOX A1 antibody, FOXA1 antibody, FOXA1_HUMAN antibody, hepatocyte nuclear factor 3 alpha antibody, Hepatocyte nuclear factor 3-alpha antibody, HNF 3A antibody, HNF-3-alpha antibody, HNF-3A antibody, HNF3A antibody, MGC33105 antibody, TCF 3A antibody, TCF-3A antibody, TCF3A antibody, Transcription factor 3A antibody

UniProt: P55317

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Carbohydrate Homeostasis