HDAC4 antibody (AA 1-227)
Quick Overview for HDAC4 antibody (AA 1-227) (ABIN7155314)
Target
See all HDAC4 AntibodiesReactivity
Host
Clonality
Conjugate
Application
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Binding Specificity
- AA 1-227
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Cross-Reactivity
- Human
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Purification
- >95%, Protein G purified
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Immunogen
- Recombinant Human Histone deacetylase 4 protein (1-227AA)
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Isotype
- IgG
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Application Notes
- Recommended dilution: IHC:1:20-1:200,
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 -
Preservative
- ProClin
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Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Storage
- -20 °C,-80 °C
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Storage Comment
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- HDAC4 (Histone Deacetylase 4 (HDAC4))
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Alternative Name
- HDAC4
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Background
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Background: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Deacetylates HSPA1A and HSPA1B at \\\'Lys-77\\\' leading to their preferential binding to co-chaperone STUB1 (PubMed:27708256).
Aliases: AHO3 antibody, BDMR antibody, EC 3.5.1.98 antibody, HA6116 antibody, HD 4 antibody, HD4 antibody, HDAC 4 antibody, HDAC A antibody, HDAC4 antibody, HDAC4_HUMAN antibody, HDACA antibody, Histone deacetylase 4 antibody, Histone Deacetylase A antibody, KIAA0288 antibody
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UniProt
- P56524
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Pathways
- Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process
Target
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