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HDAC4 antibody (AA 1-227)

This Rabbit Polyclonal antibody specifically detects HDAC4 in ELISA and IHC. It exhibits reactivity toward Human.
Catalog No. ABIN7155314

Quick Overview for HDAC4 antibody (AA 1-227) (ABIN7155314)

Target

See all HDAC4 Antibodies
HDAC4 (Histone Deacetylase 4 (HDAC4))

Reactivity

  • 120
  • 50
  • 34
  • 6
  • 6
  • 4
  • 4
  • 4
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
Human

Host

  • 109
  • 15
  • 1
Rabbit

Clonality

  • 106
  • 19
Polyclonal

Conjugate

  • 74
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  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
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  • 1
This HDAC4 antibody is un-conjugated

Application

  • 87
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ELISA, Immunohistochemistry (IHC)
  • Binding Specificity

    • 15
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    AA 1-227

    Cross-Reactivity

    Human

    Purification

    >95%, Protein G purified

    Immunogen

    Recombinant Human Histone deacetylase 4 protein (1-227AA)

    Isotype

    IgG
  • Application Notes

    Recommended dilution: IHC:1:20-1:200,

    Restrictions

    For Research Use only
  • Format

    Liquid

    Buffer

    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

    Preservative

    ProClin

    Precaution of Use

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Storage

    -20 °C,-80 °C

    Storage Comment

    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target

    HDAC4 (Histone Deacetylase 4 (HDAC4))

    Alternative Name

    HDAC4

    Background

    Background: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Deacetylates HSPA1A and HSPA1B at \\\'Lys-77\\\' leading to their preferential binding to co-chaperone STUB1 (PubMed:27708256).

    Aliases: AHO3 antibody, BDMR antibody, EC 3.5.1.98 antibody, HA6116 antibody, HD 4 antibody, HD4 antibody, HDAC 4 antibody, HDAC A antibody, HDAC4 antibody, HDAC4_HUMAN antibody, HDACA antibody, Histone deacetylase 4 antibody, Histone Deacetylase A antibody, KIAA0288 antibody

    UniProt

    P56524

    Pathways

    Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process
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