HIC1 antibody (AA 297-418) (Biotin)

Catalog No. ABIN7156017

The Rabbit Polyclonal anti-HIC1 antibody has been validated for ELISA. It is suitable to detect HIC1 in samples from Human.

Quick Overview for HIC1 antibody (AA 297-418) (Biotin) (ABIN7156017)

Target: HIC1 (Hypermethylated in Cancer 1 (HIC1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HIC1 antibody is conjugated to Biotin

Application: ELISA

Product Details anti-HIC1 Antibody (Biotin)

Binding Specificity: AA 297-418

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Hypermethylated in cancer 1 protein (297-418AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for HIC1

Target: HIC1 (Hypermethylated in Cancer 1 (HIC1))

Alternative Name: HIC1

Background:

Background: Transcriptional repressor. Recognizes and binds to the consensus sequence \'5-[CG]NG[CG]GGGCA[CA]CC-3\'. May act as a tumor suppressor. May be involved in development of head, face, limbs and ventral body wall. Involved in down-regulation of SIRT1 and thereby is involved in regulation of p53/TP53-dependent apoptotic DNA-damage responses. The specific target gene promoter association seems to be depend on corepressors, such as CTBP1 or CTBP2 and MTA1. The regulation of SIRT1 transcription in response to nutrient deprivation seems to involve CTBP1. In cooperation with MTA1 (indicative for an association with the NuRD complex) represses transcription from CCND1/cyclin-D1 and CDKN1C/p57Kip2 specifically in quiescent cells. Involved in regulation of the Wnt signaling pathway probably by association with TCF7L2 and preventing TCF7L2 and CTNNB1 association with promoters of TCF-responsive genes. Seems to repress transcription from E2F1 and ATOH1 which involves ARID1A, indicative for the participation of a distinct SWI/SNF-type chromatin-remodeling complex. Probably represses transcription from ACKR3, FGFBP1 and EFNA1.

Aliases: Hic 1 antibody, HIC ZBTB transcriptional repressor 1 antibody, Hic-1 antibody, Hic1 antibody, HIC1_HUMAN antibody, Hypermethylated in cancer 1 antibody, Hypermethylated in cancer 1 protein antibody, ZBTB29 antibody, Zinc finger and BTB domain-containing protein 29 antibody, ZNF901 antibody

UniProt: Q14526

Pathways: Positive Regulation of Response to DNA Damage Stimulus