Human Immunodeficiency Virus Vpx (HIV Vpx) (AA 1-112) antibody

Catalog No. ABIN7156073

This Rabbit Polyclonal antibody specifically detects Human Immunodeficiency Virus Vpx in ELISA and WB. It exhibits reactivity toward Human Immunodeficiency Virus (HIV).

Quick Overview for Human Immunodeficiency Virus Vpx (HIV Vpx) (AA 1-112) antibody (ABIN7156073)

Target: Human Immunodeficiency Virus Vpx (HIV Vpx)

Reactivity: Human Immunodeficiency Virus (HIV)

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: ELISA, Western Blotting (WB)

Product Details

Binding Specificity: AA 1-112

Purpose: vpx Antibody

Purification: Protein G purified

Purity: >95 %

Immunogen: Recombinant Human immunodeficiency virus type 2 subtype A Protein Vpx protein (1-112AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details

Target: Human Immunodeficiency Virus Vpx (HIV Vpx)

Alternative Name: HIV vpx

Target Type: Viral Protein

Background:

Background: Plays a role in nuclear translocation of the viral pre-integration complex (PIC), thus is required for the virus to infect non-dividing cells. Targets specific host proteins for degradation by the 26S proteasome. Acts by associating with the cellular CUL4A-DDB1 E3 ligase complex through direct interaction with host VPRPB/DCAF-1. This change in the E3 ligase substrate specificity results in the degradation of host SAMHD1. In turn, SAMHD1 depletion allows viral replication in host myeloid cells by preventing SAMHD1-mediated hydrolysis of intracellular dNTPs necessary for reverse transcription (By similarity).

Aliases: vpxProtein Vpx antibody, Viral protein X antibody, X ORF protein antibody

UniProt: P06939