FKBP6 antibody (AA 101-327)

Catalog No. ABIN7156155

The Rabbit Polyclonal anti-FKBP6 antibody has been validated for WB, ELISA, IHC and IF. It is suitable to detect FKBP6 in samples from Human.

Quick Overview for FKBP6 antibody (AA 101-327) (ABIN7156155)

Target: FKBP6 (FK506 Binding Protein 6, 36kDa (FKBP6))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FKBP6 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-FKBP6 Antibody

Binding Specificity: AA 101-327

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Inactive peptidyl-prolyl cis-trans isomerase FKBP6 protein (101-327AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for FKBP6

Target: FKBP6 (FK506 Binding Protein 6, 36kDa (FKBP6))

Alternative Name: FKBP6

Background:

Background: Co-chaperone required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Acts as a co-chaperone via its interaction with HSP90 and is required for the piRNA amplification process, the secondary piRNA biogenesis. May be required together with HSP90 in removal of 16 nucleotide ping-pong by-products from Piwi complexes, possibly facilitating turnover of Piwi complexes.

Aliases: 36 kDa FK506 binding protein antibody, 36 kDa FK506-binding protein antibody, 36 kDa FKBP antibody, EC 5.2.1.8 antibody, FK506 binding protein 6 antibody, FK506-binding protein 6 antibody, FKBP 36 antibody, FKBP-36 antibody, FKBP-6 antibody, FKBP36 antibody, fkbp6 antibody, FKBP6_HUMAN antibody, Immunophilin FKBP36 antibody, Peptidyl prolyl cis trans isomerase antibody, Peptidyl-prolyl cis-trans isomerase FKBP6 antibody, PPIase antibody, PPIase FKBP6 antibody, Rotamase antibody

UniProt: O75344

Pathways: M Phase