IRF7 antibody (AA 131-289)

Catalog No. ABIN7156631

This Rabbit Polyclonal antibody specifically detects IRF7 in ELISA, IHC and IF. It exhibits reactivity toward Human.

Quick Overview for IRF7 antibody (AA 131-289) (ABIN7156631)

Target: IRF7 (Interferon Regulatory Factor 7 (IRF7))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IRF7 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-IRF7 Antibody

Binding Specificity: AA 131-289

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Interferon regulatory factor 7 protein (131-289AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for IRF7

Target: IRF7 (Interferon Regulatory Factor 7 (IRF7))

Alternative Name: IRF7

Background:

Background: Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88-independent pathway and the TLR-activated, MyD88-dependent pathway. Required during both the early and late phases of the IFN gene induction but is more critical for the late than for the early phase. Exists in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization where along with other coactivators it can activate transcription of the type I IFN and ISG genes. Can also play a role in regulating adaptive immune responses by inducing PSMB9/LMP2 expression, either directly or through induction of IRF1. Binds to the Q promoter (Qp) of EBV nuclear antigen 1 a (EBNA1) and may play a role in the regulation of EBV latency. Can activate distinct gene expression programs in macrophages and regulate the anti-tumor properties of primary macrophages.

Aliases: IMD39 antibody, Interferon regulatory factor 7 antibody, Interferon regulatory factor 7H antibody, IRF 7 antibody, IRF 7A antibody, IRF 7H antibody, IRF-7 antibody, IRF7 antibody, IRF7_HUMAN antibody, IRF7A antibody, IRF7B antibody, IRF7C antibody, IRF7H antibody

UniProt: Q92985

Pathways: TLR Signaling, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades, Autophagy