IL1RAP antibody (AA 21-356)

Catalog No. ABIN7156734

The Rabbit Polyclonal anti-IL1RAP antibody has been validated for IHC and ELISA. It is suitable to detect IL1RAP in samples from Human.

Quick Overview for IL1RAP antibody (AA 21-356) (ABIN7156734)

Target: IL1RAP (Interleukin 1 Receptor Accessory Protein (IL1RAP))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL1RAP antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA

Product Details anti-IL1RAP Antibody

Binding Specificity: AA 21-356

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Interleukin-1 receptor accessory protein (21-356AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for IL1RAP

Target: IL1RAP (Interleukin 1 Receptor Accessory Protein (IL1RAP))

Alternative Name: IL1RAP

Background:

Background: Coreceptor for IL1RL2 in the IL-36 signaling system (By similarity). Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone, binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Secreted forms (isoforms 2 and 3) associate with secreted ligand-bound IL1R2 and increase the affinity of secreted IL1R2 for IL1B, this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.

Aliases: C3orf13 antibody, FLJ37788 antibody, IL 1 receptor accessory protein antibody, IL 1R 3 antibody, IL 1R3 antibody, IL 1RAcP antibody, IL 1RAP antibody, IL-1 receptor accessory protein antibody, IL-1R-3 antibody, IL-1R3 antibody, IL-1RAcP antibody, IL-1RAP antibody, IL1 receptor accessory protein antibody, IL1AP_HUMAN antibody, IL1R3 antibody, IL1RAcP antibody, Il1rap antibody, Interleukin 1 Accessory Protein antibody, interleukin 1 receptor 3 antibody, Interleukin 1 receptor accessory protein antibody, interleukin 1 receptor accessory protein beta antibody, Interleukin-1 receptor 3 antibody, Interleukin-1 receptor accessory protein antibody

UniProt: Q9NPH3

Pathways: NF-kappaB Signaling, Growth Factor Binding