KSR2 antibody (AA 159-296)

Catalog No. ABIN7157558

Product Details anti-KSR2 Antibody

Target: KSR2 (Kinase Suppressor of Ras 2 (KSR2))

Binding Specificity: AA 159-296

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KSR2 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Kinase suppressor of Ras 2 protein (159-296AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for KSR2

Target: KSR2 (Kinase Suppressor of Ras 2 (KSR2))

Alternative Name: KSR2 (KSR2 Products)

Synonyms: kinase suppressor of ras 2 antibody, KSR2 antibody, Ksr2 antibody

Background:

Background: Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Interaction with BRAF enhances KSR2-mediated phosphorylation of MAP2K1 (in vitro). Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production.

Aliases: FLJ25965 antibody, hKSR 2 antibody, hKSR2 antibody, Kinase suppressor of Ras 2 antibody, KSR 2 antibody, Ksr2 antibody, KSR2_HUMAN antibody

UniProt: Q6VAB6