SPC25 antibody (AA 1-224)

Catalog No. ABIN7157671

Product Details anti-SPC25 Antibody

Target: SPC25 (SPC25, NDC80 Kinetochore Complex Component, Homolog (SPC25))

Binding Specificity: AA 1-224

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SPC25 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Kinetochore protein Spc25 protein (1-224AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for SPC25

Target: SPC25 (SPC25, NDC80 Kinetochore Complex Component, Homolog (SPC25))

Alternative Name: SPC25 (SPC25 Products)

Synonyms: SPBC25 antibody, hSpc25 antibody, RGD1307811 antibody, Spbc25 antibody, spbc25 antibody, 2600017H08Rik antibody, 2610205L13Rik antibody, SPC25, NDC80 kinetochore complex component antibody, SPC25, NDC80 kinetochore complex component L homeolog antibody, SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae) antibody, SPC25 antibody, Spc25 antibody, spc25.L antibody

Background:

Background: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:14699129, PubMed:14738735). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:14738735, PubMed:14699129). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020).

Aliases: AD024 antibody, hSpc25 antibody, Kinetochore protein Spc25 antibody, SPBC25 antibody, SPC25 antibody, SPC25_HUMAN antibody, spindle pole body component 25 homolog antibody

UniProt: Q9HBM1