LGMN antibody (AA 199-312) (HRP)

Catalog No. ABIN7157974

This anti-LGMN antibody is a Rabbit Polyclonal antibody detecting LGMN in ELISA. Suitable for Human.

Quick Overview for LGMN antibody (AA 199-312) (HRP) (ABIN7157974)

Target: LGMN (Legumain (LGMN))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LGMN antibody is conjugated to HRP

Application: ELISA

Product Details anti-LGMN Antibody (HRP)

Binding Specificity: AA 199-312

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Legumain protein (199-312AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for LGMN

Target: LGMN (Legumain (LGMN))

Alternative Name: LGMN

Background:

Background: Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation (By similarity). May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system.

Aliases: AEP antibody, Asparaginyl endopeptidase antibody, cysteine 1 antibody, Cysteine protease 1 antibody, EC 3.4.22.34 antibody, Legumain antibody, LGMN antibody, LGMN_HUMAN antibody, LGMN1 antibody, Protease antibody, Protease cysteine 1 (legumain) antibody, Protease cysteine 1 antibody, PRSC1 antibody

UniProt: Q99538

Pathways: Metabolism of Steroid Hormones and Vitamin D, Activation of Innate immune Response, Toll-Like Receptors Cascades