LEF1 antibody (AA 75-216) (FITC)

Catalog No. ABIN7158658

This anti-LEF1 antibody is a Rabbit Polyclonal antibody detecting LEF1 in . Suitable for Human.

Quick Overview for LEF1 antibody (AA 75-216) (FITC) (ABIN7158658)

Target: LEF1 (Lymphoid Enhancer-Binding Factor 1 (LEF1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LEF1 antibody is conjugated to FITC

Application: Please inquire

Product Details anti-LEF1 Antibody (FITC)

Binding Specificity: AA 75-216

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Lymphoid enhancer-binding factor 1 protein (75-216AA)

Isotype: IgG

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for LEF1

Target: LEF1 (Lymphoid Enhancer-Binding Factor 1 (LEF1))

Alternative Name: LEF1

Background:

Background: Participates in the Wnt signaling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300. May play a role in hair cell differentiation and follicle morphogenesis. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1. Regulates T-cell receptor alpha enhancer function. Binds DNA in a sequence-specific manner. PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity). Isoform 3 lacks the CTNNB1 interaction domain and may be an antagonist for Wnt signaling. Isoform 5 transcriptionally activates the fibronectin promoter, binds to and represses transcription from the E-cadherin promoter in a CTNNB1-independent manner, and is involved in reducing cellular aggregation and increasing cell migration of pancreatic cancer cells. Isoform 1 transcriptionally activates MYC and CCND1 expression and enhances proliferation of pancreatic tumor cells.

Aliases: DKFZp586H0919 antibody, FLJ46390 antibody, LEF 1 antibody, LEF-1 antibody, Lef1 antibody, LEF1_HUMAN antibody, Lymphoid enhancer binding factor 1 antibody, Lymphoid enhancer-binding factor 1 antibody, T cell specific transcription factor 1 alpha antibody, T cell-specific transcription factor 1-alpha antibody, TCF 1 alpha antibody, TCF1 alpha antibody, TCF1-alpha antibody, TCF10 antibody, TCF1alpha antibody, TCF7L3 antibody, Transcription factor T cell specific 1 alpha antibody

UniProt: Q9UJU2

Pathways: WNT Signaling, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Hormone Metabolic Process, Nuclear Hormone Receptor Binding, Chromatin Binding