KARS antibody (AA 101-400) (Biotin)

Catalog No. ABIN7158684

The Rabbit Polyclonal anti-KARS antibody has been validated for ELISA. It is suitable to detect KARS in samples from Human.

Quick Overview for KARS antibody (AA 101-400) (Biotin) (ABIN7158684)

Target: KARS (Lysyl-tRNA Synthetase (KARS))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KARS antibody is conjugated to Biotin

Application: ELISA

Product Details anti-KARS Antibody (Biotin)

Binding Specificity: AA 101-400

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Lysine--tRNA ligase protein (101-400AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for KARS

Target: KARS (Lysyl-tRNA Synthetase (KARS))

Alternative Name: KARS

Background:

Background: Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA (PubMed:9278442, PubMed:18029264, PubMed:18272479). When secreted, acts as a signaling molecule that induces immune response through the activation of monocyte/macrophages (PubMed:15851690). Catalyzes the synthesis of the signaling molecule diadenosine tetraphosphate (Ap4A), and thereby mediates disruption of the complex between HINT1 and MITF and the concomitant activation of MITF transcriptional activity (PubMed:5338216, PubMed:14975237, PubMed:19524539, PubMed:23159739). (Microbial infection) Interacts with HIV-1 virus GAG protein, facilitating the selective packaging of tRNA3(Lys), the primer for reverse transcription initiation.

Aliases: CMTRIB antibody, DFNB89 antibody, EC 6.1.1.6 antibody, KARS 1 antibody, KARS 2 antibody, KARS antibody, KARS1 antibody, KARS2 antibody, KIAA0070 antibody, KRS antibody, Lysine tRNA ligase antibody, Lysine--tRNA ligase antibody, LysRS antibody, Lysyl tRNA synthetase antibody, Lysyl-tRNA synthetase antibody, SYK_HUMAN antibody

UniProt: Q15046