MAPKAP Kinase 3 antibody (AA 1-240)

Catalog No. ABIN7158991

This anti-MAPKAP Kinase 3 antibody is a Rabbit Polyclonal antibody detecting MAPKAP Kinase 3 in WB, IHC and ELISA. Suitable for Human.

Quick Overview for MAPKAP Kinase 3 antibody (AA 1-240) (ABIN7158991)

Target: MAPKAP Kinase 3 (MAPKAPK3) (Mitogen-Activated Protein Kinase-Activated Protein Kinase 3 (MAPKAPK3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAPKAP Kinase 3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-MAPKAP Kinase 3 Antibody

Binding Specificity: AA 1-240

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human MAP kinase-activated protein kinase 3 protein (1-240AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for MAPKAP Kinase 3

Target: MAPKAP Kinase 3 (MAPKAPK3) (Mitogen-Activated Protein Kinase-Activated Protein Kinase 3 (MAPKAPK3))

Alternative Name: MAPKAPK3

Background:

Background: Stress-activated serine/threonine-protein kinase involved in cytokines production, endocytosis, cell migration, chromatin remodeling and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. MAPKAPK2 and MAPKAPK3, share the same function and substrate specificity, but MAPKAPK3 kinase activity and level in protein expression are lower compared to MAPKAPK2. Phosphorylates HSP27/HSPB1, KRT18, KRT20, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to dissociate HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impair their chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally: acts by phosphorylating AU-rich elements (AREs)-binding proteins, such as TTP/ZFP36, leading to regulate the stability and translation of TNF and IL6 mRNAs. Phosphorylation of TTP/ZFP36, a major post-transcriptional regulator of TNF, promotes its binding to 14-3-3 proteins and reduces its ARE mRNA affinity leading to inhibition of dependent degradation of ARE-containing transcript. Involved in toll-like receptor signaling pathway (TLR) in dendritic cells: required for acute TLR-induced macropinocytosis by phosphorylating and activating RPS6KA3. Also acts as a modulator of Polycomb-mediated repression.

Aliases: 3pK antibody, anti MAPKAPK3 antibody, Chromosome 3p kinase antibody, EC 2.7.11.1 antibody, MAP kinase-activated protein kinase 3 antibody, MAPK activated protein kinase 3 antibody, MAPK-activated protein kinase 3 antibody, MAPK3_HUMAN antibody, MAPKAP antibody, MAPKAP kinase 3 antibody, MAPKAP-K3 antibody, MAPKAP3 antibody, MAPKAPK 3 antibody, MAPKAPK-3 antibody, Mapkapk3 antibody, MAPKAPK3 antibody antibody, Mitogen activated protein kinase activated protein kinase 3 antibody, Mitogen activated protein kinase activated protein kinase antibody, MK-3 antibody

UniProt: Q16644

Pathways: MAPK Signaling, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades