MDC1 antibody (AA 1892-2082) (Biotin)

Catalog No. ABIN7159097

This Rabbit Polyclonal antibody specifically detects MDC1 in ELISA. It exhibits reactivity toward Human.

Quick Overview for MDC1 antibody (AA 1892-2082) (Biotin) (ABIN7159097)

Target: MDC1 (Mdc1 (MDC1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MDC1 antibody is conjugated to Biotin

Application: ELISA

Product Details anti-MDC1 Antibody (Biotin)

Binding Specificity: AA 1892-2082

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Mediator of DNA damage checkpoint protein 1 protein (1892-2082AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for MDC1

Target: MDC1 (Mdc1 (MDC1))

Alternative Name: MDC1

Background:

Background: Required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. May serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by \'Ser-139\' phosphorylation of histone H2AFX. Also required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53 and apoptosis. ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1.

Aliases: Homologue to Drosophila photoreceptor protein calphotin antibody, MDC 1 antibody, Mdc1 antibody, MDC1_HUMAN antibody, Mediation of DNA damage checkpoint 1 antibody, Mediator of DNA damage checkpoint 1 antibody, Mediator of DNA damage checkpoint protein 1 antibody, NFBD 1 antibody, NFBD1 antibody, Nuclear factor with BRCT domains 1 antibody, Nuclear Factor with BRCT Domains Protein 1 antibody

UniProt: Q14676