RIKEN cDNA 4930404A10 Gene (4930404A10RIK) (AA 18-91) antibody

Catalog No. ABIN7159183

This anti- antibody is a Rabbit Polyclonal antibody detecting in ELISA and IHC. Suitable for Human.

Quick Overview for RIKEN cDNA 4930404A10 Gene (4930404A10RIK) (AA 18-91) antibody (ABIN7159183)

Target: RIKEN cDNA 4930404A10 Gene (4930404A10RIK)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Product Details

Binding Specificity: AA 18-91

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Meiosis-specific kinetochore protein (18-91AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details

Target: RIKEN cDNA 4930404A10 Gene (4930404A10RIK)

Alternative Name: MEIKIN

Background:

Background: Key regulator of kinetochore function during meiosis I: required both for mono-orientation of kinetochores on sister chromosomes and protection of centromeric cohesin from separase-mediated cleavage. Acts by facilitating kinetochore mono-orientation during meiosis I, when kinetochores on sister chromosomes face the same direction and are thus captured and pulled by spindle fibers from the same pole. Also required to prevent cleavage of cohesin at centromeres during meiosis I, possibly by acting as a regulator of the shugoshin-dependent protection pathway. Acts in collaboration with PLK1: required for PLK1 enrichment to kinetochores. Not required during meiosis II or mitosis.

Aliases: MEIKINMeiosis-specific kinetochore protein antibody

UniProt: A0A087WXM9