MAGEA2 antibody (AA 1-104) (HRP)

Catalog No. ABIN7159259

This Rabbit Polyclonal antibody specifically detects MAGEA2 in ELISA. It exhibits reactivity toward Human.

Quick Overview for MAGEA2 antibody (AA 1-104) (HRP) (ABIN7159259)

Target: MAGEA2 (Melanoma Antigen Family A, 2 (MAGEA2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAGEA2 antibody is conjugated to HRP

Application: ELISA

Product Details anti-MAGEA2 Antibody (HRP)

Binding Specificity: AA 1-104

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Melanoma-associated antigen 2 protein (1-104AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for MAGEA2

Target: MAGEA2 (Melanoma Antigen Family A, 2 (MAGEA2))

Alternative Name: MAGEA2

Background:

Background: Reduces p53/TP53 transactivation function through recruitment of HDAC3 to p53/TP53 transcription sites. Also represses p73/TP73 activity. Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination by TRIM28 potentially in presence of Ubl-conjugating enzyme UBE2H. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. Negatively regulates acetylation and sumoylation of PML and represses PML-induced p53/TP53 acetylation and activation.

Aliases: MAGEA2 antibody, MAGE2 antibody, MAGEA2A, antibody, MAGEA2B antibody, MAGE2 antibody, MAGEA2 antibody, Melanoma-associated antigen 2 antibody, Cancer/testis antigen 1.2 antibody, CT1.2 antibody, MAGE-2 antigen antibody

UniProt: P43356