MBTPS1 antibody (AA 803-1052)

Catalog No. ABIN7159380

The Rabbit Polyclonal anti-MBTPS1 antibody has been validated for ELISA and IHC. It is suitable to detect MBTPS1 in samples from Human.

Quick Overview for MBTPS1 antibody (AA 803-1052) (ABIN7159380)

Target: MBTPS1 (Membrane-Bound Transcription Factor Peptidase, Site 1 (MBTPS1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MBTPS1 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Product Details anti-MBTPS1 Antibody

Binding Specificity: AA 803-1052

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Membrane-bound transcription factor site-1 protease protein (803-1052AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for MBTPS1

Target: MBTPS1 (Membrane-Bound Transcription Factor Peptidase, Site 1 (MBTPS1))

Alternative Name: MBTPS1

Background:

Background: Serine protease that catalyzes the first step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs). Other known substrates are BDNF, GNPTAB and ATF6. Cleaves after hydrophobic or small residues, provided that Arg or Lys is in position P4. Cleaves known substrates after Arg-Ser-Val-Leu (SERBP-2), Arg-His-Leu-Leu (ATF6), Arg-Gly-Leu-Thr (BDNF) and its own propeptide after Arg-Arg-Leu-Leu. Mediates the protein cleavage of GNPTAB into subunit alpha and beta, thereby participating in biogenesis of lysosomes.

Aliases: MBTPS1 antibody, KIAA0091 antibody, S1P antibody, SKI1Membrane-bound transcription factor site-1 protease antibody, EC 3.4.21.112 antibody, Endopeptidase S1P antibody, Subtilisin/kexin-isozyme 1 antibody, SKI-1 antibody

UniProt: Q14703

Pathways: ER-Nucleus Signaling