MBTPS1 antibody (AA 180-260)

Catalog No. ABIN7225632

The Rabbit Polyclonal anti-MBTPS1 antibody (ABIN7225632) specifically detects MBTPS1 in ELISA, WB and IHC. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for MBTPS1 antibody (AA 180-260) (ABIN7225632)

Target: MBTPS1 (Membrane-Bound Transcription Factor Peptidase, Site 1 (MBTPS1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MBTPS1 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-MBTPS1 Antibody

Binding Specificity: AA 180-260

Purpose: Rabbit Anti-SKI-1 Polyclonal Antibody

Specificity: SKI-1 Polyclonal Antibody detects endogenous levels of SKI-1 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the C-terminal region of human SKI-1 at AA range: 180-260

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,IHC 1:50-300,ELISA 1:2000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for MBTPS1

Target: MBTPS1 (Membrane-Bound Transcription Factor Peptidase, Site 1 (MBTPS1))

Alternative Name: SKI-1

Background: MBTPS1, KIAA0091, S1P, SKI1, Membrane-bound transcription factor site-1 protease, Endopeptidase S1P, Subtilisin/kexin-isozyme 1, SKI-1MBTPS1 (membrane bound transcription factor peptidase, site 1) encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to the cis/medial-Golgi where a second autocatalytic event takes place and the catalytic activity is acquired. It encodes a type 1 membrane bound protease which is ubiquitously expressed and regulates cholesterol or lipid homeostasis via cleavage of substrates at non-basic residues. Mutations in MBTPS1 may be associated with lysosomal dysfunction.

Molecular Weight: 130kD

Gene ID: 8720

UniProt: Q14703

Pathways: ER-Nucleus Signaling