MITF antibody (AA 40-269)

Catalog No. ABIN7159718

This Rabbit Polyclonal antibody specifically detects MITF in IHC and ELISA. It exhibits reactivity toward Human.

Quick Overview for MITF antibody (AA 40-269) (ABIN7159718)

Target: MITF (Microphthalmia-Associated Transcription Factor (MITF))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MITF antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA

Product Details anti-MITF Antibody

Binding Specificity: AA 40-269

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Microphthalmia-associated transcription factor protein (40-269aa)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:100-1:500,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for MITF

Target: MITF (Microphthalmia-Associated Transcription Factor (MITF))

Alternative Name: MITF

Background:

Background: Transcription factor that regulates the expression of genes with essential roles in cell differentiation, proliferation and survival. Binds to M-boxes (5'-TCATGTG-3') and symmetrical DNA sequences (E-boxes) (5'-CACGTG-3') found in the promoters of target genes, such as BCL2 and tyrosinase (TYR). Plays an important role in melanocyte development by regulating the expression of tyrosinase (TYR) and tyrosinase-related protein 1 (TYRP1). Plays a critical role in the differentiation of various cell types, such as neural crest-derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium.

Aliases: Microphthalmia-associated transcription factor (Class E basic helix-loop-helix protein 32) (bHLHe32), MITF, BHLHE32

UniProt: O75030

Pathways: Chromatin Binding