SMAD7 antibody (AA 36-247) (HRP)

Catalog No. ABIN7160249

This Rabbit Polyclonal antibody specifically detects SMAD7 in ELISA. It exhibits reactivity toward Human.

Quick Overview for SMAD7 antibody (AA 36-247) (HRP) (ABIN7160249)

Target: SMAD7 (SMAD, Mothers Against DPP Homolog 7 (SMAD7))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SMAD7 antibody is conjugated to HRP

Application: ELISA

Product Details anti-SMAD7 Antibody (HRP)

Binding Specificity: AA 36-247

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Mothers against decapentaplegic homolog 7 protein (36-247AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for SMAD7

Target: SMAD7 (SMAD, Mothers Against DPP Homolog 7 (SMAD7))

Alternative Name: SMAD7

Background:

Background: Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members, has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.

Aliases: CRCS3 antibody, FLJ16482 antibody, hSMAD 7 antibody, hSMAD7 antibody, MAD (mothers against decapentaplegic Drosophila) homolog 7 antibody, MAD antibody, Mad homolog 7 antibody, MAD homolog 8 antibody, MAD mothers against decapentaplegic homolog 7 antibody, MADH 7 antibody, MADH 8 antibody, MADH6 antibody, MADH7 antibody, MADH8 antibody, Mothers Against Decapentaplegic Drosophila Homolog of 6 antibody, Mothers Against Decapentaplegic Drosophila Homolog of 7 antibody, Mothers against decapentaplegic homolog 7 antibody, Mothers against decapentaplegic homolog 8 antibody, Mothers against DPP homolog 7 antibody, Mothers against DPP homolog 8 antibody, SMA- AND MAD-RELATED PROTEIN 7 antibody, SMAD 7 antibody, SMAD antibody, SMAD family member 7 antibody, SMAD, mothers against DPP homolog 7 (Drosophila) antibody, SMAD, mothers against DPP homolog 7 antibody, SMAD6 antibody, Smad7 antibody, SMAD7_HUMAN antibody

UniProt: O15105

Pathways: Interferon-gamma Pathway, Cell-Cell Junction Organization