MBNL1 antibody (AA 1-382) (HRP)

Catalog No. ABIN7160360

This Rabbit Polyclonal antibody specifically detects MBNL1 in ELISA. It exhibits reactivity toward Human.

Quick Overview for MBNL1 antibody (AA 1-382) (HRP) (ABIN7160360)

Target: MBNL1 (Muscleblind-like Protein 1 (MBNL1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MBNL1 antibody is conjugated to HRP

Application: ELISA

Product Details anti-MBNL1 Antibody (HRP)

Binding Specificity: AA 1-382

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Muscleblind-like protein 1 protein (1-382AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for MBNL1

Target: MBNL1 (Muscleblind-like Protein 1 (MBNL1))

Alternative Name: MBNL1

Background:

Background: Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. Regulates the TNNT2 exon 5 skipping through competition with U2AF2. Inhibits the formation of the spliceosome A complex on intron 4 of TNNT2 pre-mRNA. Binds to the stem-loop structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Binds to the 5\'-YGCU(U/G)Y-3\'consensus sequence. Binds to the IR RNA. Binds to expanded CUG repeat RNA, which folds into a hairpin structure containing GC base pairs and bulged, unpaired U residues.

Aliases: EXP antibody, EXP35 antibody, EXP40 antibody, EXP42 antibody, KIAA0428 antibody, MBNL antibody, MBNL protein antibody, MBNL1 antibody, MBNL1_HUMAN antibody, Muscleblind 41kD isoform antibody, Muscleblind like antibody, Muscleblind like protein 1 antibody, Muscleblind like splicing regulator 1 antibody, Muscleblind-like protein 1 antibody, Triplet expansion RNA binding protein antibody, Triplet-expansion RNA-binding protein antibody

UniProt: Q9NR56

Pathways: Ribonucleoprotein Complex Subunit Organization