METTL14 antibody (AA 24-206) (HRP)

Catalog No. ABIN7160804

Product Details anti-METTL14 Antibody (HRP)

Target: METTL14 (Methyltransferase Like 14 (METTL14))

Binding Specificity: AA 24-206

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This METTL14 antibody is conjugated to HRP

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human N6-adenosine-methyltransferase subunit METTL14 protein (24-206AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for METTL14

Target: METTL14 (Methyltransferase Like 14 (METTL14))

Alternative Name: METTL14 (METTL14 Products)

Synonyms: RGD1304822 antibody, G430022H21Rik antibody, mKIAA1627 antibody, zgc:77296 antibody, methyltransferase like 14 antibody, methyltransferase like 14 L homeolog antibody, Mettl14 antibody, mettl14.L antibody, METTL14 antibody, mettl14 antibody

Background:

Background: N6-methyltransferase that methylates adenosine residues of some mRNAs and acts as a regulator of the circadian clock and differentiation of embryonic stem cells. N6-methyladenosine (m6A), which takes place at the 5\\\'-[AG]GAC-3\\\' consensus sites of some mRNAs, plays a role in the efficiency of mRNA splicing, processing and mRNA stability (PubMed:24316715, PubMed:24407421, PubMed:25719671). M6A regulates the length of the circadian clock: acts as a early pace-setter in the circadian loop. M6A also acts as a regulator of mRNA stability: in embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization (By similarity).

Aliases: KIAA1627 antibody, MET14_HUMAN antibody, Methyltransferase like 14 antibody, Methyltransferase-like protein 14 antibody, METTL14 antibody, N6-adenosine-methyltransferase subunit METTL14 antibody, OTTHUMP00000219837 antibody

UniProt: Q9HCE5