MME antibody (AA 386-617)

Catalog No. ABIN7161162

The Rabbit Polyclonal anti-MME antibody has been validated for IHC and ELISA. It is suitable to detect MME in samples from Human.

Quick Overview for MME antibody (AA 386-617) (ABIN7161162)

Target: MME (Membrane Metallo-Endopeptidase (MME))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MME antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA

Product Details anti-MME Antibody

Binding Specificity: AA 386-617

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Neprilysin protein (386-617AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:100-1:500,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for MME

Target: MME (Membrane Metallo-Endopeptidase (MME))

Alternative Name: MME

Background:

Background: Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids (PubMed:15283675, PubMed:8168535). Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond (PubMed:17101991). Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9 (PubMed:15283675). Involved in the degradation of atrial natriuretic factor (ANF) (PubMed:2531377, PubMed:2972276). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers (PubMed:20876573).

Aliases: Atriopeptidase antibody, CALLA antibody, CD10 antibody, CD10 antigen antibody, Common acute lymphocytic leukemia antigen antibody, DKFZp686O16152 antibody, EC 3.4.24.11 antibody, Enkephalinase antibody, EPN antibody, Membrane metallo endopeptidase (neutral endopeptidase, enkephalinase) antibody, Membrane metallo endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10) antibody, Membrane metallo endopeptidase antibody, Membrane metallo endopeptidase variant 1 antibody, Membrane metallo endopeptidase variant 2 antibody, Membrane metalloendopeptidase antibody, Membrane metalloendopeptidase neutral endopeptidase enkephalinase antibody, Membrane metalloendopeptidase neutral endopeptidase enkephalinase CALLA CD10 antibody, Membrane metalloendopeptidase variant 1 antibody, Membrane metalloendopeptidase variant 2 antibody, MGC126681 antibody, MGC126707 antibody, MME antibody, NEP antibody, NEP_HUMAN antibody, Neprilysin antibody, neprilysin-390 antibody, neprilysin-411 antibody, Neutral endopeptidase 24.11 antibody, Neutral endopeptidase antibody, Neutral endopeptidase, membrane-associated antibody, SFE antibody, Skin fibroblast elastase antibody

UniProt: P08473

Pathways: RTK Signaling, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Smooth Muscle Cell Migration