NOTCH3 antibody (AA 1301-1496) (Biotin)

Catalog No. ABIN7161303

The Rabbit Polyclonal anti-NOTCH3 antibody has been validated for ELISA. It is suitable to detect NOTCH3 in samples from Human.

Quick Overview for NOTCH3 antibody (AA 1301-1496) (Biotin) (ABIN7161303)

Target: NOTCH3 (Notch 3 (NOTCH3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NOTCH3 antibody is conjugated to Biotin

Application: ELISA

Product Details anti-NOTCH3 Antibody (Biotin)

Binding Specificity: AA 1301-1496

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Neurogenic locus notch homolog protein 3 protein (1301-1496AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for NOTCH3

Target: NOTCH3 (Notch 3 (NOTCH3))

Alternative Name: NOTCH3

Background:

Background: Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity).

Aliases: CADASIL antibody, CASIL antibody, NOTC3_HUMAN antibody, Notch 3 antibody, Notch 3 intracellular domain antibody, Notch homolog 3 antibody, Notch3 antibody

UniProt: Q9UM47

Pathways: Notch Signaling