ASAH2 antibody (AA 255-506)

Catalog No. ABIN7161486

The Rabbit Polyclonal anti-ASAH2 antibody has been validated for WB, ELISA, IHC and IF. It is suitable to detect ASAH2 in samples from Human.

Quick Overview for ASAH2 antibody (AA 255-506) (ABIN7161486)

Target: ASAH2 (N-Acylsphingosine Amidohydrolase (Non-Lysosomal Ceramidase) 2 (ASAH2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ASAH2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-ASAH2 Antibody

Binding Specificity: AA 255-506

Cross-Reactivity: Human, Rat

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Neutral ceramidase protein (255-506AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:500,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for ASAH2

Target: ASAH2 (N-Acylsphingosine Amidohydrolase (Non-Lysosomal Ceramidase) 2 (ASAH2))

Alternative Name: ASAH2

Background:

Background: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 6.5-8.5. Acts as a key regulator of sphingolipid signaling metabolites by generating sphingosine at the cell surface. Acts as a repressor of apoptosis both by reducing C16-ceramide, thereby preventing ceramide-induced apoptosis, and generating sphingosine, a precursor of the antiapoptotic factor sphingosine 1-phosphate. Probably involved in the digestion of dietary sphingolipids in intestine by acting as a key enzyme for the catabolism of dietary sphingolipids and regulating the levels of bioactive sphingolipid metabolites in the intestinal tract.

Aliases: Acylsphingosine deacylase 2 antibody, AI585898 antibody, ASAH2 antibody, ASAH2_HUMAN antibody, BCDase antibody, hCD antibody, HNAC1 antibody, LCDase antibody, MGC129777 antibody, mitochondrial ceramidase antibody, N acylsphingosine amidohydrolase (non lysosomal ceramidase) 2 antibody, N acylsphingosine amidohydrolase 2 antibody, N CDase antibody, N-acylsphingosine amidohydrolase 2 antibody, N-CDase antibody, NCDase antibody, Neutral ceramidase soluble form antibody, Non lysosomal ceramidase antibody, Non-lysosomal ceramidase antibody

UniProt: Q9NR71