NUMBL antibody (AA 447-576) (HRP)

Catalog No. ABIN7162088

This Rabbit Polyclonal antibody specifically detects NUMBL in ELISA. It exhibits reactivity toward Human.

Quick Overview for NUMBL antibody (AA 447-576) (HRP) (ABIN7162088)

Target: NUMBL (Numb Homolog (Drosophila)-Like (NUMBL))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NUMBL antibody is conjugated to HRP

Application: ELISA

Product Details anti-NUMBL Antibody (HRP)

Binding Specificity: AA 447-576

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Numb-like protein (447-576AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for NUMBL

Target: NUMBL (Numb Homolog (Drosophila)-Like (NUMBL))

Alternative Name: NUMBL

Background:

Background: Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the \'Lys-48\'-linked polyubiquitination and degradation of TRAF6 in cortical neurons.

Aliases: CAG 3A antibody, CAG3A antibody, CTG 3a antibody, CTG3a antibody, NBL antibody, NUMB Drosophilia Homolog Like antibody, Numb homolog (Drosophila) like antibody, Numb homolog like antibody, Numb like protein antibody, NUMB R antibody, Numb-like protein antibody, Numb-R antibody, Numb-related gene antibody, Numb-related protein antibody, NUMBL antibody, NUMBL_HUMAN antibody, NUMBLIKE antibody, NUMBR antibody, TNRC 23 antibody, TNRC23 antibody, Trinucleotide repeat-containing gene 23 antibody

UniProt: Q9Y6R0

Pathways: Cell-Cell Junction Organization