OSBP antibody (AA 628-802) (Biotin)

Catalog No. ABIN7162396

Product Details anti-OSBP Antibody (Biotin)

Target: OSBP (Oxysterol Binding Protein (OSBP))

Binding Specificity: AA 628-802

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This OSBP antibody is conjugated to Biotin

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Oxysterol-binding protein 1 protein (628-802AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for OSBP

Target: OSBP (Oxysterol Binding Protein (OSBP))

Alternative Name: OSBP (OSBP Products)

Synonyms: CG6708 antibody, Dmel\\CG6708 antibody, OSBP-Dm antibody, osbp antibody, OSBP1 antibody, 1110018F06Rik antibody, AW559088 antibody, mKIAA4220 antibody, Oxysterol binding protein antibody, oxysterol binding protein antibody, Osbp antibody, OSBP antibody

Background:

Background: Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum (PubMed:24209621). Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol (PubMed:15746430, PubMed:17428193). Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydroxycholesterol causes its disassembly (PubMed:15746430). Regulates cholesterol efflux by decreasing ABCA1 stability (PubMed:18450749).

Aliases: OSBP 1 antibody, OSBP antibody, OSBP1_HUMAN antibody, Oxysterol binding protein 1 antibody, Oxysterol-binding protein 1 antibody

UniProt: P22059