PTF1A antibody (AA 224-325)

Catalog No. ABIN7162562

This Rabbit Polyclonal antibody specifically detects PTF1A in WB, ELISA, IHC and IF. It exhibits reactivity toward Human.

Quick Overview for PTF1A antibody (AA 224-325) (ABIN7162562)

Target: PTF1A (Pancreas Specific Transcription Factor, 1a (PTF1A))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PTF1A antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-PTF1A Antibody

Binding Specificity: AA 224-325

Cross-Reactivity: Human, Mouse, Rat

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Pancreas transcription factor 1 subunit alpha protein (224-325AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for PTF1A

Target: PTF1A (Pancreas Specific Transcription Factor, 1a (PTF1A))

Alternative Name: PTF1A

Background:

Background: Transcription factor implicated in the cell fate determination in various organs. Binds to the E-box consensus sequence 5\\\'-CANNTG-3\\\'. Plays a role in early and late pancreas development and differentiation. Important for determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. May be involved in the maintenance of exocrine pancreas-specific gene expression including ELA1 and amylase. Required for the formation of pancreatic acinar and ductal cells. Plays an important role in cerebellar development. Directly regulated by FOXN4 and RORC during retinal development, FOXN4-PTF1A pathway plays a central role in directing the differentiation of retinal progenitors towards horizontal and amacrine fates.

Aliases: bHLH transcription factor p48 antibody, bHLHa29 antibody, Class A basic helix-loop-helix protein 29 antibody, Class II bHLH protein PTF1A antibody, Exocrine pancreas specific transcription factor p48 antibody, p48 DNA binding subunit of transcription factor PTF1 antibody, p48 DNA-binding subunit of transcription factor PTF1 antibody, PACA antibody, PAGEN2 antibody, Pancreas specific transcription factor 1a antibody, Pancreas transcription factor 1 subunit alpha antibody, Pancreas-specific transcription factor 1a antibody, PTF 1A antibody, PTF1 p48 antibody, PTF1-p48 antibody, Ptf1a antibody, PTF1A_HUMAN antibody, PTF1P48 antibody

UniProt: Q7RTS3

Pathways: Retinoic Acid Receptor Signaling Pathway