Sphingomyelin Synthase 2 antibody (AA 1-79)

Catalog No. ABIN7163135

Product Details anti-Sphingomyelin Synthase 2 Antibody

Target: Sphingomyelin Synthase 2 (SGMS2)

Binding Specificity: AA 1-79

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Sphingomyelin Synthase 2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human, Rat

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Phosphatidylcholine:ceramide cholinephosphotransferase 2 protein (1-79AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:5000, IHC:1:500-1:1000, IF:1:200-1:500,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for Sphingomyelin Synthase 2

Target: Sphingomyelin Synthase 2 (SGMS2)

Alternative Name: SGMS2 (SGMS2 Products)

Synonyms: SMS2 antibody, 4933405A16Rik antibody, 5133401H06Rik antibody, AI854299 antibody, RGD1305778 antibody, spermatin antibody, sphingomyelin synthase 2 antibody, sgms2 antibody, SGMS2 antibody, Sgms2 antibody

Background:

Background: Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide. Plasma membrane SMS2 can also convert phosphatidylethanolamine (PE) to ceramide phosphatidylethanolamine (CPE). Major form in liver. Required for cell growth in certain cell types. Regulator of cell surface levels of ceramide, an important mediator of signal transduction and apoptosis. Regulation of sphingomyelin (SM) levels at the cell surface affects insulin sensitivity.

Aliases: MGC26963 antibody, Phosphatidylcholine:ceramide cholinephosphotransferase 2 antibody, SGMS 2 antibody, Sgms2 antibody, SM synthase antibody, SMS 2 antibody, SMS2 antibody, SMS2_HUMAN antibody, Sphingomyelin synthase 2 antibody

UniProt: Q8NHU3