PIEZO1 antibody (AA 2230-2420)

Catalog No. ABIN7163444

This Rabbit Polyclonal antibody specifically detects PIEZO1 in IHC and ELISA. It exhibits reactivity toward Human.

Quick Overview for PIEZO1 antibody (AA 2230-2420) (ABIN7163444)

Target: PIEZO1 (Piezo-Type Mechanosensitive Ion Channel Component 1 (PIEZO1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PIEZO1 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA

Product Details anti-PIEZO1 Antibody

Binding Specificity: AA 2230-2420

Purpose: PIEZO1 Antibody

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Piezo-type mechanosensitive ion channel component 1 protein (2230-2420AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for PIEZO1

Target: PIEZO1 (Piezo-Type Mechanosensitive Ion Channel Component 1 (PIEZO1))

Alternative Name: PIEZO1

Background:

Background: Pore-forming subunit of a mechanosensitive non-specific cation channel (PubMed:23479567, PubMed:23695678). Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling (PubMed:20016066). In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing. Acts as shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation (PubMed:25119035). Plays a key role in blood vessel formation and vascular structure in both development and adult physiology (By similarity).

Aliases: DHS antibody, Fam38a antibody, Family with sequence similarity 38 member A antibody, KIAA0233 antibody, Membrane protein induced by beta-amyloid treatment antibody, Mib antibody, PIEZ1_HUMAN antibody, Piezo-type mechanosensitive ion channel component 1 antibody, PIEZO1 antibody, Protein FAM38A antibody, Protein FAM38B antibody, Protein PIEZO1 antibody

UniProt: Q92508