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Senataxin (SETX) (AA 2401-2677) antibody

SETX Reactivity: Human ELISA, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7164533
  • Target See all Senataxin (SETX) Antibodies
    Senataxin (SETX)
    Binding Specificity
    • 15
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 2401-2677
    Reactivity
    • 15
    • 10
    • 1
    Human
    Host
    • 23
    • 2
    Rabbit
    Clonality
    • 22
    • 3
    Polyclonal
    Conjugate
    • 7
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Un-conjugated
    Application
    • 13
    • 13
    • 9
    • 6
    • 4
    • 3
    • 3
    • 2
    • 1
    ELISA, Immunohistochemistry (IHC)
    Cross-Reactivity
    Human
    Purification
    >95%, Protein G purified
    Immunogen
    Recombinant Human Probable helicase senataxin protein (2401-2677AA)
    Isotype
    IgG
  • Application Notes
    Recommended dilution: IHC:1:20-1:200,
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    Senataxin (SETX)
    Alternative Name
    SETX (SETX Products)
    Synonyms
    ALS4 antibody, SETX antibody, wu:fj92h09 antibody, AOA2 antibody, SCAR1 antibody, bA479K20.2 antibody, Als4 antibody, Sen1 antibody, AW060766 antibody, mKIAA0625 antibody, A130090N03 antibody, A930037J23Rik antibody, RGD1565575 antibody, senataxin antibody, SETX antibody, setx antibody, Setx antibody
    Background

    Background: Probable RNA/DNA helicase involved in diverse aspects of RNA metabolism and genomic integrity. Plays a role in transcription regulation by its ability to modulate RNA Polymerase II (Pol II) binding to chromatin and through its interaction with proteins involved in transcription (PubMed:19515850, PubMed:21700224). Contributes to the mRNA splicing efficiency and splice site selection (PubMed:19515850). Required for the resolution of R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site, allowing XRN2 recruitment and XRN2-mediated degradation of the downstream cleaved RNA and hence efficient RNA polymerase II (RNAp II) transcription termination (PubMed:19515850, PubMed:21700224). Required for the 3\' transcriptional termination of PER1 and CRY2, thus playing an important role in the circadian rhythm regulation (By similarity). Involved in DNA double-strand breaks damage response generated by oxidative stress (PubMed:17562789). In association with RRP45, targets the RNA exosome complex to sites of transcription-induced DNA damage (PubMed:24105744). Plays a role in the development and maturation of germ cells: essential for male meiosis, acting at the interface of transcription and meiotic recombination, and in the process of gene silencing during meiotic sex chromosome inactivation (MSCI) (By similarity). May be involved in telomeric stability through the regulation of telomere repeat-containing RNA (TERRA) transcription (PubMed:21112256). Plays a role in neurite outgrowth in hippocampal cells through FGF8-activated signaling pathways. Inhibits retinoic acid-induced apoptosis (PubMed:21576111).

    Aliases: ALS4 antibody, Amyotrophic lateral sclerosis 4 protein antibody, AOA2 antibody, bA479K20.2 antibody, DKFZp781B151 antibody, FLJ12840 antibody, FLJ43459 antibody, KIAA0625 antibody, Probable helicase senataxin antibody, SCAR1 antibody, SEN1 homolog antibody, Setx antibody, SETX_HUMAN antibody

    UniProt
    Q7Z333
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