PSTPIP1 antibody (AA 157-416)

Catalog No. ABIN7164772

This anti-PSTPIP1 antibody is a Rabbit Polyclonal antibody detecting PSTPIP1 in WB, ELISA and IHC. Suitable for Human.

Quick Overview for PSTPIP1 antibody (AA 157-416) (ABIN7164772)

Target: PSTPIP1 (Proline-serine-threonine Phosphatase Interacting Protein 1 (PSTPIP1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PSTPIP1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-PSTPIP1 Antibody

Binding Specificity: AA 157-416

Cross-Reactivity: Human, Mouse

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Proline-serine-threonine phosphatase-interacting protein 1 protein (157-416AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for PSTPIP1

Target: PSTPIP1 (Proline-serine-threonine Phosphatase Interacting Protein 1 (PSTPIP1))

Alternative Name: PSTPIP1

Background:

Background: Involved in regulation of the actin cytoskeleton. May regulate WAS actin-bundling activity. Bridges the interaction between ABL1 and PTPN18 leading to ABL1 dephosphorylation. May play a role as a scaffold protein between PTPN12 and WAS and allow PTPN12 to dephosphorylate WAS. Has the potential to physically couple CD2 and CD2AP to WAS. Acts downstream of CD2 and CD2AP to recruit WAS to the T-cell:APC contact site so as to promote the actin polymerization required for synapse induction during T-cell activation (By similarity). Down-regulates CD2-stimulated adhesion through the coupling of PTPN12 to CD2. Also has a role in innate immunity and the inflammatory response. Recruited to inflammasomes by MEFV. Induces formation of pyroptosomes, large supramolecular structures composed of oligomerized PYCARD dimers which form prior to inflammatory apoptosis. Binding to MEFV allows MEFV to bind to PYCARD and facilitates pyroptosome formation. Regulates endocytosis and cell migration in neutrophils.

Aliases: CD2 antigen binding protein 1 antibody, CD2 binding protein 1 antibody, CD2 cytoplasmic tail binding protein antibody, CD2-binding protein 1 antibody, CD2BP1 antibody, CD2BP1L antibody, CD2BP1S antibody, H PIP antibody, H-PIP antibody, HPIP antibody, PAPAS antibody, PEST phosphatase interacting protein 1 antibody, PEST phosphatase-interacting protein 1 antibody, PPIP1_HUMAN antibody, Proline serine threonine phosphatase interacting protein 1 antibody, Proline-serine-threonine phosphatase-interacting protein 1 antibody, PSTPIP antibody, Pstpip1 antibody

UniProt: O43586