PSMB5 antibody (AA 106-188)

Catalog No. ABIN7164982

The Rabbit Polyclonal anti-PSMB5 antibody (ABIN7164982) specifically detects PSMB5 in WB, IHC, ELISA and IF. The antibody is reactive with Human samples.

Quick Overview for PSMB5 antibody (AA 106-188) (ABIN7164982)

Target: PSMB5 (Proteasome (Prosome, Macropain) Subunit, beta Type, 5 (PSMB5))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PSMB5 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Product Details anti-PSMB5 Antibody

Binding Specificity: AA 106-188

Purpose: PSMB5 Antibody

Cross-Reactivity: Mouse

Purification: Protein G purified

Purity: >95 %

Immunogen: Recombinant Human Proteasome subunit beta type-5 protein (106-188AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for PSMB5

Target: PSMB5 (Proteasome (Prosome, Macropain) Subunit, beta Type, 5 (PSMB5))

Alternative Name: PSMB5

Background:

Background: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH . The proteasome has an ATP-dependent proteolytic activity. This unit is responsible of the chymotrypsin-like activity of the proteasome and is one of the principal target of the proteasome inhibitor bortezomib. May catalyze basal processing of intracellular antigens. Plays a role in the protection against oxidative damage through the Nrf2-ARE pathway (By similarity).

Aliases: DKFZp459C139 antibody, EC 3.4.25.1 antibody, LMPX antibody, Macropain epsilon chain antibody, MB1 antibody, MGC104214 antibody, MGC118075 antibody, MGC134464 antibody, Multicatalytic endopeptidase complex epsilon chain antibody, Proteasome (prosome, macropain) subunit, beta type, 5 antibody, Proteasome beta 5 subunit antibody, Proteasome catalytic subunit 3 antibody, Proteasome chain 6 antibody, Proteasome epsilon chain antibody, Proteasome subunit beta type-5 antibody, Proteasome subunit MB1 antibody, Proteasome subunit X antibody, Proteasome subunit, beta type, 5 antibody, Proteasome subunit, beta-5 antibody, PSB5_HUMAN antibody, PSMB5 antibody, PSX large multifunctional protease X antibody, X antibody

UniProt: P28074

Pathways: Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA