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AGO2 antibody (AA 517-818) (HRP)

AGO2 Reactivity: Human ELISA Host: Rabbit Polyclonal HRP
Catalog No. ABIN7165094
$328.90
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  • Target See all AGO2 Antibodies
    AGO2 (Argonaute 2 (AGO2))
    Binding Specificity
    • 9
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 517-818
    Reactivity
    • 40
    • 23
    • 13
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 40
    • 4
    Rabbit
    Clonality
    • 30
    • 14
    Polyclonal
    Conjugate
    • 21
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    This AGO2 antibody is conjugated to HRP
    Application
    • 26
    • 18
    • 15
    • 9
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    ELISA
    Cross-Reactivity
    Human
    Purification
    >95%, Protein G purified
    Immunogen
    Recombinant Human Protein argonaute-2 protein (517-818AA)
    Isotype
    IgG
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    AGO2 (Argonaute 2 (AGO2))
    Alternative Name
    AGO2 (AGO2 Products)
    Synonyms
    EIF2C2 antibody, T19E23.7 antibody, T19E23_7 antibody, argonaute 2 antibody, Q10 antibody, Eif2c2 antibody, Argonaute2 antibody, eif2c1 antibody, eif2c2 antibody, 1110029L17Rik antibody, 2310051F07Rik antibody, AI225898 antibody, AL022874 antibody, AW546247 antibody, ENSMUSG00000072493 antibody, Gerp95 antibody, Gm10365 antibody, mKIAA4215 antibody, AGO2 antibody, AG02 antibody, AGO 2 antibody, Ago-2 antibody, Ago2 antibody, CG13452 antibody, CG7439 antibody, Dm Ago2 antibody, Dmel\\CG7439 antibody, ago antibody, ago-2 antibody, ago2 antibody, dAGO2 antibody, dAgo2 antibody, eIF2C2 antibody, argonaute 2, RISC catalytic component antibody, Argonaute family protein antibody, argonaute 2, RISC catalytic component L homeolog antibody, argonaute RISC catalytic subunit 2 antibody, argonaute RISC catalytic component 2 antibody, Argonaute 2 antibody, AGO2 antibody, Ago2 antibody, ago2.L antibody, ago2 antibody
    Background

    Background: Required for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). The minimal RISC appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the mRNA specifically by AGO2. Binding of RISC to a partially complementary mRNA results in silencing through inhibition of translation, and this is independent of endonuclease activity. May inhibit translation initiation by binding to the 7-methylguanosine cap, thereby preventing the recruitment of the translation initiation factor eIF4-E. May also inhibit translation initiation via interaction with EIF6, which itself binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit. The inhibition of translational initiation leads to the accumulation of the affected mRNA in cytoplasmic processing bodies (P-bodies), where mRNA degradation may subsequently occur. In some cases RISC-mediated translational repression is also observed for miRNAs that perfectly match the 3' untranslated region (3-UTR). Can also up-regulate the translation of specific mRNAs under certain growth conditions. Binds to the AU element of the 3-UTR of the TNF (TNF-alpha) mRNA and up-regulates translation under conditions of serum starvation. Also required for transcriptional gene silencing (TGS), in which short RNAs known as antigene RNAs or agRNAs direct the transcriptional repression of complementary promoter regions.

    Aliases: Ago 2 antibody, AGO2_HUMAN antibody, Argonaute 2 antibody, argonaute 2, RISC catalytic component antibody, Argonaute RISC catalytic component 2 antibody, Argonaute2 antibody, CTA-204B4.6 antibody, dAgo2 antibody, eIF 2C 2 antibody, eIF-2C 2 antibody, eIF2C 2 antibody, Eif2c2 antibody, Eukaryotic translation initiation factor 2C 2 antibody, Eukaryotic translation initiation factor 2C subunit 2 antibody, hAgo2 antibody, MGC3183 antibody, PAZ Piwi domain protein antibody, PPD antibody, Protein argonaute-2 antibody, Protein slicer antibody, Q10 antibody, Slicer protein antibody

    UniProt
    Q9UKV8
    Pathways
    Fc-epsilon Receptor Signaling Pathway, Regulatory RNA Pathways, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Ribonucleoprotein Complex Subunit Organization
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