IWS1 antibody (AA 570-819)

Catalog No. ABIN7165661

This Rabbit Polyclonal antibody specifically detects IWS1 in WB, ELISA and IHC. It exhibits reactivity toward Human.

Quick Overview for IWS1 antibody (AA 570-819) (ABIN7165661)

Target: IWS1 (IWS1 Homolog (IWS1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IWS1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-IWS1 Antibody

Binding Specificity: AA 570-819

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Protein IWS1 homolog protein (570-819AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for IWS1

Target: IWS1 (IWS1 Homolog (IWS1))

Alternative Name: IWS1

Background:

Background: Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription.

Aliases: DKFZp761G0123 antibody, FLJ10006 antibody, FLJ14655 antibody, FLJ32319 antibody, Interacts with Spt6 antibody, iws1 antibody, IWS1 homolog antibody, IWS1-like protein antibody, IWS1_HUMAN antibody, IWS1L antibody, MGC126375 antibody, MGC126376 antibody, OTTHUMP00000162262 antibody, Protein IWS1 homolog antibody

UniProt: Q96ST2