NTAN1 antibody (AA 219-310)

Catalog No. ABIN7165837

Product Details anti-NTAN1 Antibody

Target: NTAN1 (N-terminal Asparagine Amidase (NTAN1))

Binding Specificity: AA 219-310

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NTAN1 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Protein N-terminal asparagine amidohydrolase protein (219-310AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:500-1:1000, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for NTAN1

Target: NTAN1 (N-terminal Asparagine Amidase (NTAN1))

Alternative Name: NTAN1 (NTAN1 Products)

Synonyms: PNAA antibody, PNAD antibody, N-terminal Asn amidase antibody, N-terminal asparagine amidase antibody, Ntan1 antibody, NTAN1 antibody

Background:

Background: Side-chain deamidation of N-terminal asparagine residues to aspartate. Required for the ubiquitin-dependent turnover of intracellular proteins that initiate with Met-Asn. These proteins are acetylated on the retained initiator methionine and can subsequently be modified by the removal of N-acetyl methionine by acylaminoacid hydrolase (AAH). Conversion of the resulting N-terminal asparagine to aspartate by PNAD renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. This enzyme does not act on substrates with internal or C-terminal asparagines and does not act on glutamine residues in any position, nor on acetylated N-terminal peptidyl Asn.

Aliases: NTAN1 antibody, Protein N-terminal asparagine amidohydrolase antibody, EC 3.5.1.121 antibody, Protein NH2-terminal asparagine amidohydrolase antibody, PNAA antibody, Protein NH2-terminal asparagine deamidase antibody, PNAD antibody, Protein N-terminal Asn amidase antibody, Protein N-terminal asparagine amidase antibody, Protein NTN-amidase antibody

UniProt: Q96AB6