QKI antibody (AA 1-341)

Catalog No. ABIN7166001

Product Details anti-QKI Antibody

Target: QKI (Protein Quaking (QKI))

Binding Specificity: AA 1-341

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This QKI antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Protein quaking protein (1-341AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for QKI

Target: QKI (Protein Quaking (QKI))

Alternative Name: QKI (QKI Products)

Synonyms: Hqk antibody, QK antibody, QK1 antibody, QK3 antibody, hqkI antibody, 1110003F05Rik antibody, 1500005P18 antibody, QkI antibody, l(17)-1Wis antibody, l17Wis1 antibody, Qki antibody, CQKI antibody, QKI-5 antibody, PqkI antibody, BqkI antibody, qk antibody, qk1 antibody, quaking antibody, Xqua antibody, qki antibody, EQKI antibody, EqkI antibody, QKI, KH domain containing RNA binding antibody, quaking antibody, QKI, KH domain containing, RNA binding S homeolog antibody, QKI, KH domain containing, RNA binding L homeolog antibody, QKI antibody, Qk antibody, qki.S antibody, qki.L antibody, Qki antibody

Background:

Background: RNA-binding protein that plays a central role in myelinization (PubMed:16641098). Binds to the 5\\\'-NACUAAY-N(1,20)-UAAY-3\\\' RNA core sequence. Regulates target mRNA stability (PubMed:23630077). In addition, acts by regulating pre-mRNA splicing, mRNA export and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B. Regulator of oligodendrocyte differentiation and maturation in the brain that may play a role in myelin and oligodendrocyte dysfunction in schizophrenia (PubMed:16641098). Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG pre-mRNA. Acts as a translational repressor (By similarity).

Aliases: DKFZp586I0923 antibody, HKQ antibody, Homolog of mouse quaking QKI KH domain RNA binding protein antibody, Hqk antibody, HQK1 antibody, HqkI antibody, OTTHUMP00000017581 antibody, OTTHUMP00000017582 antibody, OTTHUMP00000017583 antibody, Protein quaking antibody, QK antibody, QK1 antibody, QK3 antibody, QKI antibody, QKI_HUMAN antibody, QKI1 antibody, Quaking homolog antibody, Quaking homolog KH domain RNA binding antibody, Quaking homolog KH domain RNA binding mouse antibody, Quaking isoform 1 antibody, Quaking protein antibody, RNA binding protein HQK antibody

UniProt: Q96PU8