RICTOR antibody (AA 1-245)

Catalog No. ABIN7167113

This Rabbit Polyclonal antibody specifically detects RICTOR in IHC and ELISA. It exhibits reactivity toward Human.

Quick Overview for RICTOR antibody (AA 1-245) (ABIN7167113)

Target: RICTOR (RPTOR Independent Companion of mTOR, Complex 2 (RICTOR))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RICTOR antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA

Product Details anti-RICTOR Antibody

Binding Specificity: AA 1-245

Purpose: RICTOR Antibody

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Rapamycin-insensitive companion of mTOR protein (1-245AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for RICTOR

Target: RICTOR (RPTOR Independent Companion of mTOR, Complex 2 (RICTOR))

Alternative Name: RICTOR

Background:

Background: Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 \\\'Ser-473\\\' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on \\\'Thr-308\\\' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at \\\'Ser-422\\\'. mTORC2 also modulates the phosphorylation of PRKCA on \\\'Ser-657\\\'. Plays an essential role in embryonic growth and development.

Aliases: AVO3 antibody, AVO3 homolog antibody, DKFZp686B11164 antibody, hAVO3 antibody, KIAA1999 antibody, Likely ortholog of mouse TORC2 specific protein AVO3 (S. cerevisiae) antibody, mAVO3 antibody, MGC39830 antibody, PIA antibody, Pianissimo antibody, Rapamycin insensitive companion of mTOR antibody, Rapamycin-insensitive companion of mTOR antibody, Rictor antibody, RICTR antibody, RICTR_HUMAN antibody, RPTOR independent companion of MTOR complex 2 antibody, TORC2 specific protein AVO3 antibody

UniProt: Q6R327

Pathways: Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Actin Filament Polymerization, CXCR4-mediated Signaling Events