REST antibody (AA 250-350) (Biotin)

Catalog No. ABIN7167426

The Rabbit Polyclonal anti-REST antibody has been validated for ELISA. It is suitable to detect REST in samples from Human.

Quick Overview for REST antibody (AA 250-350) (Biotin) (ABIN7167426)

Target: REST (RE1-Silencing Transcription Factor (REST))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This REST antibody is conjugated to Biotin

Application: ELISA

Product Details anti-REST Antibody (Biotin)

Binding Specificity: AA 250-350

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human RE1-silencing transcription factor protein (250-350AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for REST

Target: REST (RE1-Silencing Transcription Factor (REST))

Alternative Name: REST

Background:

Background: Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. Transcriptional repression by REST-CDYL via the recruitment of histone methyltransferase EHMT2 may be important in transformation suppression.

Aliases: Neural Restrictive Silencer Factor antibody, Neural-restrictive silencer factor antibody, Neuron Restrictive Silencer Factor antibody, NRSF antibody, RE1 silencing transcription factor antibody, RE1-silencing transcription factor antibody, Repressor binding to the X2 box antibody, rest antibody, REST protein antibody, REST_HUMAN antibody, X2 box repressor antibody, XBR antibody

UniProt: Q13127

Pathways: Negative Regulation of Hormone Secretion, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Chromatin Binding, Positive Regulation of Endopeptidase Activity