ARHGAP18 antibody (AA 389-577) (Biotin)

Catalog No. ABIN7167936

Product Details anti-ARHGAP18 Antibody (Biotin)

Target: ARHGAP18 (rho GTPase Activating Protein 18 (ARHGAP18))

Binding Specificity: AA 389-577

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ARHGAP18 antibody is conjugated to Biotin

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Rho GTPase-activating protein 18 protein (389-577AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for ARHGAP18

Target: ARHGAP18 (rho GTPase Activating Protein 18 (ARHGAP18))

Alternative Name: ARHGAP18 (ARHGAP18 Products)

Synonyms: 4833419J07Rik antibody, AI314906 antibody, AI843501 antibody, MacGAP antibody, SENEX antibody, bA307O14.2 antibody, MGC146282 antibody, DKFZp469I1011 antibody, Rho GTPase activating protein 18 antibody, Rho GTPase activating protein 18 L homeolog antibody, Arhgap18 antibody, ARHGAP18 antibody, arhgap18 antibody, arhgap18.L antibody

Background:

Background: Rho GTPase activating protein that suppresses F-actin polymerization by inhibiting Rho. Rho GTPase activating proteins act by converting Rho-type GTPases to an inactive GDP-bound state (PubMed:21865595). Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation. Acts downstream of YAP1 and inhibits actin polymerization, which in turn reduces nuclear localization of YAP1 (PubMed:25778702). Regulates cell shape, spreading, and migration (PubMed:21865595).

Aliases: 4833419J07Rik antibody, AI314906 antibody, AI843501 antibody, Arhgap18 antibody, bA307O14.2 antibody, FLJ25728 antibody, MacGAP antibody, MGC126757 antibody, MGC138145 antibody, OTTHUMP00000017190 antibody, OTTMUSP00000028606 antibody, RHG18_HUMAN antibody, Rho GTPase-activating protein 18 antibody, Rho-type GTPase-activating protein 18 antibody, SENEX antibody

UniProt: Q8N392