ARHGEF5 antibody (AA 433-507)

Catalog No. ABIN7167986

This Rabbit Polyclonal antibody specifically detects ARHGEF5 in ELISA and IHC. It exhibits reactivity toward Human.

Quick Overview for ARHGEF5 antibody (AA 433-507) (ABIN7167986)

Target: ARHGEF5 (rho Guanine Nucleotide Exchange Factor (GEF) 5 (ARHGEF5))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ARHGEF5 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Product Details anti-ARHGEF5 Antibody

Binding Specificity: AA 433-507

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Rho guanine nucleotide exchange factor 5 protein (433-507AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for ARHGEF5

Target: ARHGEF5 (rho Guanine Nucleotide Exchange Factor (GEF) 5 (ARHGEF5))

Alternative Name: ARHGEF5

Background:

Background: Guanine nucleotide exchange factor which activates Rho GTPases (PubMed:15601624). Strongly activates RHOA (PubMed:15601624). Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1 (By similarity). Involved in regulation of cell shape and actin cytoskeletal organization (PubMed:15601624). Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia (PubMed:14662653). Required for SRC-induced podosome formation (By similarity). Involved in positive regulation of immature dendritic cell migration (By similarity).

Aliases: ARHG5_HUMAN antibody, ARHGEF 5 antibody, ARHGEF5 antibody, DKFZp686N1969 antibody, ephexin 3 antibody, Ephexin-3 antibody, GEF 5 antibody, GEF5 antibody, Guanine nucleotide regulatory protein TIM antibody, Oncogene TIM antibody, P60 antibody, p60 TIM antibody, Rho guanine nucleotide exchange factor (GEF) 5 antibody, Rho guanine nucleotide exchange factor 5 antibody, TIM 1 antibody, TIM antibody, TIM1 antibody, Transforming immortalized mammary oncogene antibody

UniProt: Q12774