RHOH antibody (AA 1-188)

Catalog No. ABIN7168038

The Rabbit Polyclonal anti-RHOH antibody has been validated for ELISA, IF and IHC. It is suitable to detect RHOH in samples from Human.

Quick Overview for RHOH antibody (AA 1-188) (ABIN7168038)

Target: RHOH (Ras Homolog Family Member H (RHOH))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RHOH antibody is un-conjugated

Application: ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC)

Product Details anti-RHOH Antibody

Binding Specificity: AA 1-188

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Rho-related GTP-binding protein RhoH protein (1-188AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for RHOH

Target: RHOH (Ras Homolog Family Member H (RHOH))

Alternative Name: RHOH

Background:

Background: Negative regulator of hematopoietic progenitor cell proliferation, survival and migration. Critical regulator of thymocyte development and T-cell antigen receptor (TCR) signaling by mediating recruitment and activation of ZAP70. Required for phosphorylation of CD3Z, membrane translocation of ZAP70 and subsequent activation of the ZAP70-mediated pathways. Essential for efficient beta-selection and positive selection by promoting the ZAP70-dependent phosphorylation of the LAT signalosome during pre-TCR and TCR signaling. Crucial for thymocyte maturation during DN3 to DN4 transition and during positive selection. Plays critical roles in mast cell function by facilitating phosphorylation of SYK in Fc epsilon RI-mediated signal transduction. Essential for the phosphorylation of LAT, LCP2, PLCG1 and PLCG2 and for Ca(2+) mobilization in mast cells. Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins. Inhibits the activation of NF-kappa-B by TNF and IKKB and the activation of CRK/p38 by TNF. Inhibits activities of RAC1, RHOA and CDC42. Negatively regulates leukotriene production in neutrophils.

Aliases: ARHH antibody, GTP binding protein TTF antibody, GTP-binding protein TTF antibody, OTTHUMP00000125213 antibody, Ras homolog gene family member H antibody, Rho related GTP binding protein antibody, Rho related GTP binding protein RhoH antibody, Rho-related GTP-binding protein RhoH antibody, RHOH antibody, RHOH_HUMAN antibody, Translocation three four protein antibody, TTF antibody, TTF translocation three four antibody

UniProt: Q15669