Rubicon antibody (AA 518-733) (HRP)

Catalog No. ABIN7168476

The Rabbit Polyclonal anti-Rubicon antibody has been validated for ELISA. It is suitable to detect Rubicon in samples from Human.

Quick Overview for Rubicon antibody (AA 518-733) (HRP) (ABIN7168476)

Target: Rubicon (KIAA0226) (KIAA0226)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Rubicon antibody is conjugated to HRP

Application: ELISA

Product Details anti-Rubicon Antibody (HRP)

Binding Specificity: AA 518-733

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Run domain Beclin-1-interacting and cysteine-rich domain-containing protein (518-733AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for Rubicon

Target: Rubicon (KIAA0226) (KIAA0226)

Alternative Name: RUBCN

Background:

Background: Inhibits PIK3C3 activity, under basal conditions negatively regulates PI3K complex II (PI3KC3-C2) function in autophagy. Negatively regulates endosome maturation and degradative endocytic trafficking and impairs autophagosome maturation process. Can sequester UVRAG from association with a class C Vps complex (possibly the HOPS complex) and negatively regulates Rab7 activation (PubMed:20974968, PubMed:21062745).

Aliases: Baron antibody, Beclin 1 associated RUN domain containing protein antibody, Beclin-1 associated RUN domain containing protein antibody, hypothetical protein LOC9711 antibody, Kiaa0226 antibody, OTTHUMP00000208021 antibody, OTTHUMP00000208023 antibody, OTTHUMP00000208024 antibody, RUBIC_HUMAN antibody, Rubicon antibody, RUN domain and cysteine rich domain containing, Beclin 1 interacting protein antibody, Run domain Beclin 1 interacting and cystein rich containing protein antibody, Run domain Beclin-1 interacting and cysteine-rich containing protein antibody, RUN domain protein as Beclin 1 interacting and cysteine rich containing antibody

UniProt: Q92622

Pathways: Autophagy