Rubicon antibody (AA 859-972)

Catalog No. ABIN7193445

Product Details anti-Rubicon Antibody

Target: Rubicon (KIAA0226) (KIAA0226)

Binding Specificity: AA 859-972

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Rubicon antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: purified

Immunogen: Purified recombinant fragment of human RUBCN (AA: 859-972) expressed in E. coli.

Clone: 4F5B5

Isotype: IgG1

Application Details

Application Notes: WB:1:500 - 1:2000, ELISA:1:10000,

Restrictions: For Research Use only

Handling

Buffer: Purified antibody in PBS with 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: 4°C, -20°C for long term storage

Target Details for Rubicon

Target: Rubicon (KIAA0226) (KIAA0226)

Alternative Name: RUBCN (KIAA0226 Products)

Synonyms: RUBICON antibody, 5330403K09 antibody, Kiaa0226 antibody, Rubicon antibody, mKIAA0226 antibody, RUN and cysteine rich domain containing beclin 1 interacting protein antibody, KIAA0226 antibody, RUN domain and cysteine-rich domain containing, Beclin 1-interacting protein antibody, RUBCN antibody, KIAA0226 antibody, Rubcn antibody

Background:

Description: The protein encoded by this gene is a negative regulator of autophagy and endocytic trafficking and controls endosome maturation. This protein contains two conserved domains, an N-terminal RUN domain and a C-terminal DUF4206 domain. The RUN domain is involved in Ras-like GTPase signaling, and the DUF4206 domain contains a diacylglycerol (DAG) binding-like motif. Mutation in this gene results in deletion of the DAG binding-like motif and causes a recessive ataxia. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Aliases: SCAR15, RUBICON, KIAA0226

Molecular Weight: 108.6 kDa

Gene ID: 9711

Pathways: Autophagy