Selenoprotein N antibody (AA 135-219)

Catalog No. ABIN7168771

Product Details anti-Selenoprotein N Antibody

Target: Selenoprotein N (SELENON)

Binding Specificity: AA 135-219

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Selenoprotein N antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Cross-Reactivity: Human, Rat

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Selenoprotein N protein (135-219AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:5000,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for Selenoprotein N

Target: Selenoprotein N (SELENON)

Alternative Name: SELENON (SELENON Products)

Background:

Background: Isoform 2: Plays an important role in cell protection against oxidative stress and in the regulation of redox-related calcium homeostasis. Regulates the calcium level of the ER by protecting the calcium pump ATP2A2 against the oxidoreductase ERO1A-mediated oxidative damage. Within the ER, ERO1A activity increases the concentration of H(2)O(2), which attacks the luminal thiols in ATP2A2 and thus leads to cysteinyl sulfenic acid formation (-SOH) and SEPN1 reduces the SOH back to free thiol (-SH), thus restoring ATP2A2 activity (PubMed:25452428). Acts as a modulator of ryanodine receptor (RyR) activity: protects RyR from oxidation due to increased oxidative stress, or directly controls the RyR redox state, regulating the RyR-mediated calcium mobilization required for normal muscle development and differentiation (PubMed:19557870, PubMed:18713863).

Aliases: CFTD antibody, MDRS1 antibody, RSMD1 antibody, RSS antibody, Selenoprotein N antibody, Selenoprotein N, 1 antibody, SelN antibody, SELN_HUMAN antibody, sepn1 antibody

UniProt: Q9NZV5