ULK2 antibody (AA 211-276) (HRP)

Catalog No. ABIN7169212

This anti-ULK2 antibody is a Rabbit Polyclonal antibody detecting ULK2 in ELISA. Suitable for Human.

Quick Overview for ULK2 antibody (AA 211-276) (HRP) (ABIN7169212)

Target: ULK2 (Unc-51 Like Kinase 2 (ULK2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ULK2 antibody is conjugated to HRP

Application: ELISA

Product Details anti-ULK2 Antibody (HRP)

Binding Specificity: AA 211-276

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Serine/threonine-protein kinase ULK2 protein (211-276AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for ULK2

Target: ULK2 (Unc-51 Like Kinase 2 (ULK2))

Alternative Name: ULK2

Background:

Background: Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and a negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK, also acts as a negative regulator of AMPK through phosphorylation of the AMPK subunits PRKAA1, PRKAB2 and PRKAG1. May phosphorylate ATG13/KIAA0652, FRS2, FRS3 and RPTOR, however such data need additional evidences. Not involved in ammonia-induced autophagy or in autophagic response of cerebellar granule neurons (CGN) to low potassium concentration. Plays a role early in neuronal differentiation and is required for granule cell axon formation: may govern axon formation via Ras-like GTPase signaling and through regulation of the Rab5-mediated endocytic pathways within developing axons.

Aliases: ATG1B antibody, KIAA0623 antibody, Serine/threonine protein kinase ULK2 antibody, Serine/threonine-protein kinase ULK2 antibody, ULK2 antibody, ULK2_HUMAN antibody, Unc 51 (C. elegans) like kinase 2 antibody, Unc 51 like autophagy activating kinase 2 antibody, Unc 51 like kinase 2 antibody, Unc-51-like kinase 2 antibody, Unc51.2 antibody

UniProt: Q8IYT8

Pathways: Regulation of Cell Size, Autophagy