VRK1 antibody (AA 257-396)

Catalog No. ABIN7169217

The Rabbit Polyclonal anti-VRK1 antibody is suitable to detect VRK1 in samples from Human. It has been validated for WB, ELISA and IHC.

Quick Overview for VRK1 antibody (AA 257-396) (ABIN7169217)

Target: VRK1 (Vaccinia Related Kinase 1 (VRK1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This VRK1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-VRK1 Antibody

Binding Specificity: AA 257-396

Purpose: VRK1 Antibody

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Serine/threonine-protein kinase VRK1 protein (257-396AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for VRK1

Target: VRK1 (Vaccinia Related Kinase 1 (VRK1))

Alternative Name: VRK1

Background:

Background: Serine/threonine kinase involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation. Acts by mediating phosphorylation of downstream target protein. Phosphorylates \\\'Thr-18\\\' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2. Phosphorylates casein and histone H3. Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm. Phosphorylates ATF2 which activates its transcriptional activity.

Aliases: MGC117401 antibody, MGC138280 antibody, MGC142070 antibody, PCH1 antibody, PCH1A antibody, Serine/threonine protein kinase VRK1 antibody, Serine/threonine-protein kinase VRK1 antibody, Vaccinia related kinase 1 antibody, Vaccinia virus B1R related kinase 1 antibody, Vaccinia-related kinase 1 antibody, VRK1 antibody, VRK1_HUMAN antibody

UniProt: Q99986