WNK2 antibody (AA 1177-1464) (FITC)

Catalog No. ABIN7169228

This Rabbit Polyclonal antibody specifically detects WNK2 in . It exhibits reactivity toward Human.

Quick Overview for WNK2 antibody (AA 1177-1464) (FITC) (ABIN7169228)

Target: WNK2 (WNK Lysine Deficient Protein Kinase 2 (WNK2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This WNK2 antibody is conjugated to FITC

Application: Please inquire

Product Details anti-WNK2 Antibody (FITC)

Binding Specificity: AA 1177-1464

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Serine/threonine-protein kinase WNK2 protein (1177-1464AA)

Isotype: IgG

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for WNK2

Target: WNK2 (WNK Lysine Deficient Protein Kinase 2 (WNK2))

Alternative Name: WNK2

Background:

Background: Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5. Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression. Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulation depends on phosphorylation of MAP2K1 by PAK1. WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity.

Aliases: WNK2 antibody, KIAA1760 antibody, PRKWNK2 antibody, SDCCAG43 antibody, P/OKcl.13 antibody, Serine/threonine-protein kinase WNK2 antibody, EC 2.7.11.1 antibody, Antigen NY-CO-43 antibody, Protein kinase lysine-deficient 2 antibody, Protein kinase with no lysine 2 antibody, Serologically defined colon cancer antigen 43 antibody

UniProt: Q9Y3S1

Pathways: Photoperiodism