SPPL2B antibody (AA 492-592) (FITC)

Catalog No. ABIN7169629

This anti-SPPL2B antibody is a Rabbit Polyclonal antibody detecting SPPL2B in . Suitable for Human.

Quick Overview for SPPL2B antibody (AA 492-592) (FITC) (ABIN7169629)

Target: SPPL2B (Signal Peptide Peptidase-Like 2B (SPPL2B))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SPPL2B antibody is conjugated to FITC

Application: Please inquire

Product Details anti-SPPL2B Antibody (FITC)

Binding Specificity: AA 492-592

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Signal peptide peptidase-like 2B protein (492-592AA)

Isotype: IgG

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for SPPL2B

Target: SPPL2B (Signal Peptide Peptidase-Like 2B (SPPL2B))

Alternative Name: SPPL2B

Background:

Background: Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in ITM2B and TNF processing (PubMed:16829952, PubMed:16829951, PubMed:17965014, PubMed:19114711, PubMed:22194595). Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus (PubMed:16829952, PubMed:16829951). May play a role in the regulation of innate and adaptive immunity (PubMed:16829952). Catalyzes the intramembrane cleavage of the simian foamy virus processed leader peptide gp18 of the envelope glycoprotein gp130 dependently of prior ectodomain shedding by furin or furin-like proprotein convertase (PC)-mediated cleavage proteolysis (PubMed:23132852).

Aliases: SPPL2B antibody, IMP4 antibody, KIAA1532 antibody, PSL1 antibody, Signal peptide peptidase-like 2B antibody, SPP-like 2B antibody, SPPL2b antibody, EC 3.4.23.- antibody, Intramembrane protease 4 antibody, IMP-4 antibody, Presenilin homologous protein 4 antibody, PSH4 antibody, Presenilin-like protein 1 antibody

UniProt: Q8TCT7