SIGIRR antibody (AA 1-120)

Catalog No. ABIN7169723

This Rabbit Polyclonal antibody specifically detects SIGIRR in WB, IHC and ELISA. It exhibits reactivity toward Human.

Quick Overview for SIGIRR antibody (AA 1-120) (ABIN7169723)

Target: SIGIRR (Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SIGIRR antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-SIGIRR Antibody

Binding Specificity: AA 1-120

Purpose: SIGIRR Antibody

Cross-Reactivity: Mouse

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Single Ig IL-1-related receptor protein (1-120AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for SIGIRR

Target: SIGIRR (Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR))

Alternative Name: SIGIRR

Background:

Background: Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.

Aliases: Ig IL1 related receptor antibody, MGC110992 antibody, SIGIR_HUMAN antibody, SIGIRR antibody, Single Ig IL 1 related receptor antibody, Single Ig IL-1-related receptor antibody, Single Ig IL-1R-related molecule antibody, Single Ig IL1R Related Molecule antibody, Single immunoglobulin and toll interleukin 1 receptor (TIR) domain antibody, Single immunoglobulin and toll interleukin 1 receptor domain antibody, Single immunoglobulin domain containing IL1R related protein antibody, Single immunoglobulin domain IL1R1 related antibody, Single immunoglobulin domain-containing IL1R-related protein antibody, TIR 8 antibody, TIR8 antibody, Toll/interleukin 1 receptor 8 antibody, Toll/interleukin-1 receptor 8 antibody

UniProt: Q6IA17

Pathways: Toll-Like Receptors Cascades